Regina Sarfaty (born 1932) is an American operatic mezzo-soprano who had an active career during the 1950s through the 1980s. Sarfaty first rose to prominence through her work at the Santa Fe Opera and the New York City Opera during the late 1950s. She later enjoyed international success in the 1960s and 1970s, and had a particularly lengthy career singing with the Zurich Opera.