Now That's What I Call Music! 41 was released on February 7, 2012. It is the 41st edition of the Now! series in the United States. The album debuted at number three on the Billboard 200 for the week ending February 24, 2012, after selling 142,000 units in its first week of release. A month later, it returned to number three on the chart and jumped to number one on the Billboard Digital Albums chart after a one-day, 25-cent promotion of its downloadable version by Google Play and Amazon.com pushed digital sales up 1,367%.

Now! 41 features the number-one Billboard Hot 100 hits, "Sexy and I Know It" and "Someone Like You".